A Three‐Step Chemoenzymatic Cascade Synthesis of Miconazole Analogues Based on the Asymmetric Synthesis of β‐Heteroaryl Amino Alcohols via Ketoreductases.

The inside cover picture shows an approach for the asymmetric synthesis of miconazole analogues through a chemoenzymatic cascade. Beginning with 2-bromoacetophenone derivatives, the pathway involves chemical synthesis and two engineered stereocomplementary ketoreductases, enabling the synthesis of 50 pairs of β-heteroaryl amino alcohols with high conversions and stereoselectivities, along with 10 pairs of miconazole analogues with promising yields and remarkable enantiopurities. Details can be found in the Research Article by Jiali Fang, and co-workers. (J. Fang, Y. Xu, H. Ren, C. Huang, W. Zhang, X. Jia, S. You, B. Qin, Adv. Synth. Catal. 2023, 365, XXXX–XXXX; DOI: 10.1002/adsc.202300740)