碳二亚胺
生物相容性
柠檬酸
庆大霉素
壳聚糖
氨基糖苷
化学
组织工程
角膜
表面改性
生物医学工程
材料科学
抗生素
高分子化学
生物化学
眼科
医学
有机化学
物理化学
作者
Yang Liu,Huiyu Liu,Chuanlei Zhang,Yanhui Kong,Cheng Chen,Wengen Gao,Xiaowei Xi,Linhong Deng
标识
DOI:10.1016/j.ijbiomac.2023.126791
摘要
Corneal disease is an important clinical problem that affects millions of blind people and keratoplasty is currently the most successful treatment for corneal blindness. Unfortunately, there is a very high risk of bacterial infection during corneal transplantation. In this study, we proposed a novel synthetic collagen-based film for corneal therapy, and we effectively incorporated aminoglycoside gentamicin molecules onto the surface of the collagen film. We anticipate that this collagen-based substance will be antimicrobial and repair corneal tissue damage. Three steps were used to create this gentamicin-modified carboxylated collagen film, including: (i) Cross-link the collagen molecules with 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide and n-hydroxysuccinimide to create a collagen (Col) film. (ii) Citric acid was used to modify the Col film's surface in order to increase the number of carboxyl groups there (ColCA). (iii) Gentamicin molecules were grafted onto the surface of ColCA film by forming amide bonds (ColCA-GM). We discovered that this ColCA-GM film has good physicochemical properties and excellent biocompatibility. Furthermore, it was demonstrated that treating collagen films with citric acid significantly improved the antibacterial properties of ColCA-GM film. The outcomes point to a variety of potential applications for this novel film in corneal tissue engineering.
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