溶解度
柠檬酸
溶解
差示扫描量热法
化学
尿酸
山奈酚
核化学
傅里叶变换红外光谱
扫描电子显微镜
色散(光学)
材料科学
类黄酮
化学工程
食品科学
生物化学
有机化学
复合材料
工程类
物理
抗氧化剂
光学
热力学
作者
Danni Song,Changqing Xie,Rong Yang,Aijinxiu Ma,Honghui Zhao,Fengmao Zou,Xiangrong Zhang,Xu Zhao
标识
DOI:10.1515/ijfe-2022-0214
摘要
Abstract Kaempferol (KPF) is a flavonoid compound, which has a variety of pharmacological activities, and widely exists in daily diet. However, its application is limited due to poor solubility. Citric acid (CA) is a common food additive with high solubility. In this study, solid dispersion (SD) was prepared with CA as the carrier to improve the solubility of KPF. KPF-CA-SD (weight ratio 1:20) was obtained by ultrasonic for 20 min at 40 °C. The in vitro dissolution of KPF in SD was increased from about 50% to more than 80%. The physicochemical characterizations were analyzed by X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscope. In hyperuricemia mice, KPF-SD (equivalent to 100 mg/kg KPF) can effectively reduce serum uric acid and exert nephroprotective effects. In conclusion, the preparation of SD with CA might provide a safe and effective selection to facilitate application of KPF in food and medicine.
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