胸腺嘧啶
碱基
氢键
聚合物
两亲性
材料科学
超分子化学
共聚物
胶束
纳米技术
级联
超分子聚合物
组合化学
化学
分子
DNA
水溶液
有机化学
生物化学
色谱法
复合材料
作者
Caiyun Yang,Yixuan Du,Qiaoran Li,Xinru Gao,Peng Zha,Wanli Zhan,Ketao Liu,Feihu Bi,Zan Hua,Guang Yang
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2024-04-04
卷期号:13 (4): 468-474
标识
DOI:10.1021/acsmacrolett.4c00037
摘要
Glycopolymer-based supramolecular glycoassemblies with signal-driven cascade morphological deformation and accessible surface engineering toward bioinspired functional glycomaterials have attracted much attention due to their diverse applications in fundamental and practical scenarios. Herein, we achieved the cascade morphological transformation and surface engineering of a nucleobase-containing polymeric glycovesicle through exploiting the bioinspired complementary multiple hydrogen bonds of complementary nucleobases. First, the synthesized thymine-containing glycopolymers (PGal30-b-PTAm249) are capable of self-assembling into well-defined glycovesicles. Several kinds of amphiphilic adenine-containing block copolymers with neutral, positive, and negative charges were synthesized to engineer the glycovesicles through the multiple hydrogen bonds between adenine and thymine. A cascade of morphological transformations from vesicles to ruptured vesicles with tails, to worm-like micelles, and finally to spherical micelles were observed via continuously adding the adenine-containing polymer into the thymine-containing glycovesicles. Furthermore, the surface charge properties of these glyconano-objects can be facilely regulated through incorporating various adenine-containing polymers. This work demonstrates the potential application of a unique bioinspired approach to precisely engineer the morphology and surface properties of glycovesicles for boosting their biological applications.
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