清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Properties of REM sleep alterations with epilepsy

神经科学 癫痫 心理学 睡眠(系统调用) 听力学 医学 计算机科学 操作系统
作者
Yoko Ikoma,Yusuke Takahashi,Daichi Sasaki,Kosuke Matsui
出处
期刊:Brain [Oxford University Press]
卷期号:146 (6): 2431-2442 被引量:14
标识
DOI:10.1093/brain/awac499
摘要

Abstract It is usually assumed that individuals rest during sleep. However, coordinated neural activity that presumably requires high energy consumption is increased during REM sleep. Here, using freely moving male transgenic mice, the local brain environment and astrocyte activity during REM sleep were examined using the fibre photometry method with an optical fibre inserted deep into the lateral hypothalamus, a region that is linked with controlling sleep and metabolic state of the entire brain. Optical fluctuations of endogenous autofluorescence of the brain parenchyma or fluorescence of sensors for Ca2+ or pH expressed in astrocytes were examined. Using a newly devised method for analysis, changes in cytosolic Ca2+ and pH in astrocytes and changes in the local brain blood volume (BBV) were extracted. On REM sleep, astrocytic Ca2+ decreases, pH decreases (acidification) and BBV increases. Acidification was unexpected, as an increase in BBV would result in efficient carbon dioxide and/or lactate removal, which leads to alkalinization of the local brain environment. Acidification could be a result of increased glutamate transporter activity due to enhanced neuronal activity and/or aerobic metabolism in astrocytes. Notably, optical signal changes preceded the onset of the electrophysiological property signature of REM sleep by ∼20–30 s. This suggests that changes in the local brain environment have strong control over the state of neuronal cell activity. With repeated stimulation of the hippocampus, seizure response gradually develops through kindling. After a fully kindled state was obtained with multiple days of stimuli, the optical properties of REM sleep at the lateral hypothalamus were examined again. Although a negative deflection of the detected optical signal was observed during REM sleep after kindling, the estimated component changed. The decrease in Ca2+ and increase in BBV were minimal, and a large decrease in pH (acidification) emerged. This acidic shift may trigger an additional gliotransmitter release from astrocytes, which could lead to a state of hyperexcitable brain. As the properties of REM sleep change with the development of epilepsy, REM sleep analysis may serve as a biomarker of epileptogenesis severity. REM sleep analysis may also predict whether a specific REM sleep episode triggers post-sleep seizures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
asheng98完成签到 ,获得积分10
2秒前
吃小孩的妖怪完成签到 ,获得积分10
11秒前
诗蕊完成签到 ,获得积分10
11秒前
WYnini完成签到 ,获得积分10
25秒前
whuhustwit完成签到,获得积分10
39秒前
zxx完成签到 ,获得积分10
46秒前
652183758完成签到 ,获得积分10
53秒前
抹缇卡完成签到 ,获得积分10
1分钟前
浩浩完成签到 ,获得积分10
1分钟前
陆黑暗完成签到 ,获得积分10
1分钟前
1分钟前
科研佟完成签到 ,获得积分10
1分钟前
cadcae完成签到,获得积分10
1分钟前
迅速的念芹完成签到 ,获得积分10
1分钟前
焚心结完成签到 ,获得积分10
1分钟前
六等于三二一完成签到 ,获得积分10
1分钟前
快乐的七宝完成签到 ,获得积分10
2分钟前
Ray完成签到 ,获得积分10
2分钟前
2分钟前
serenity完成签到 ,获得积分10
2分钟前
ChatGPT发布了新的文献求助10
2分钟前
瘦瘦煎饼完成签到 ,获得积分10
2分钟前
ChatGPT发布了新的文献求助10
2分钟前
三脸茫然完成签到 ,获得积分10
2分钟前
ChatGPT完成签到,获得积分10
2分钟前
研友完成签到 ,获得积分10
3分钟前
fffffffffffffff完成签到 ,获得积分10
3分钟前
8R60d8完成签到,获得积分0
3分钟前
lunyu完成签到 ,获得积分10
3分钟前
坚强志泽完成签到 ,获得积分10
3分钟前
俊逸的白梦完成签到 ,获得积分10
3分钟前
橘子海完成签到 ,获得积分10
3分钟前
Tianju完成签到,获得积分10
3分钟前
研友_Lmg1gZ完成签到,获得积分10
3分钟前
huazhangchina完成签到 ,获得积分10
3分钟前
高雯完成签到,获得积分10
3分钟前
芝诺的乌龟完成签到 ,获得积分0
4分钟前
张颖完成签到 ,获得积分10
4分钟前
欢呼的茗茗完成签到 ,获得积分10
4分钟前
丹妮完成签到 ,获得积分10
4分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052644
求助须知:如何正确求助?哪些是违规求助? 2709863
关于积分的说明 7418252
捐赠科研通 2354395
什么是DOI,文献DOI怎么找? 1246007
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921