Biomineralization of Copper‐Celastrol Nanohybrids for Synergistic Antitumor Therapy

⁺ serves both as a coordination center for drug encapsulation and as a therapeutic agent for chemodynamic therapy (CDT). The pH-responsive dissociation of metal-phenolic coordination ensures tumor-specific drug release, while the biomineralization process inherently enhances aqueous stability and bioavailability. Moreover, the rational design of Cel-TA-Cu NP enables a synergistic anticancer effect by simultaneously triggering apoptotic signaling pathways and amplifying oxidative stress-induced cytotoxicity. Overall, this biomineralization-based nanoplatform not only overcomes the inherent limitations of Cel but also integrates CDT to markedly enhance therapeutic efficacy, providing a promising avenue for advanced cancer treatment.