Development of an electrochemical sensor based on Ni-Bio-MOF and a molecular imprinted polymer for determination of diclofenac: electrochemical and DFT investigations

, relative standard deviation (RSD) of 3.3%, and reproducibility of 96.2%. Real samples of healthy human blood serum and DCF tablets were used to evaluate the practical application of the CPE/Ni-Bio-MOF/MIP-PL-Met electrochemical sensor. This method is simple, low-cost, with good limited detection, high sensitivity, and selectivity. The interactions of PL-Met with DCF were studied at the B3LYP/6-311++G(d,p) level of theory in both gaseous and aqueous phases. Additionally, the computational methodology investigated the thermodynamic stability of the proposed configurations and the role of hydrogen bonds in this system.