Structural Modifications on Dopamine Molecules toward Polydopamine Applications

Abstract Polydopamine (PDA) is a synthetic material synthesized through the oxidative self‐polymerization of dopamine under alkaline conditions. This material emulates the adhesive properties of mussel foot proteins, allowing the formation of robust and stable organic coatings on various surfaces. Researchers have attempted to identify and improve the surface‐coating properties of PDA by incorporating additional organic functional groups. This review explores the structural modifications of dopamine molecules at the organic chemistry level, with a focus on changes in the catechol moiety and aliphatic amines, and examines their impact on the applications of PDA. The flexibility of these modifications underscores their importance for optimizing PDA coatings for a wide range of applications.