催化作用
过渡金属
纳米技术
超分子化学
反应性(心理学)
化学
超分子催化
活细胞
组合化学
生化工程
材料科学
有机化学
分子
生物
病理
工程类
医学
生物系统
替代医学
作者
Catriona C. James,Bas de Bruin,Joost N. H. Reek
标识
DOI:10.1002/anie.202306645
摘要
The importance of transition metal catalysis is exemplified by its wide range of applications, for example in the synthesis of chemicals, natural products, and pharmaceuticals. However, one relatively new application is for carrying out new-to-nature reactions inside living cells. The complex environment of a living cell is not welcoming to transition metal catalysts, as a diverse range of biological components have the potential to inhibit or deactivate the catalyst. Here we review the current progress in the field of transition metal catalysis, and evaluation of catalysis efficiency in living cells and under biological (relevant) conditions. Catalyst poisoning is a ubiquitous problem in this field, and we propose that future research into the development of physical and kinetic protection strategies may provide a route to improve the reactivity of catalysts in cells.
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