四氢吡喃
四氢呋喃
化学
立体化学
圆二色性
戒指(化学)
差向异构体
消炎药
植物化学
有机化学
生物化学
生物
药理学
溶剂
作者
Li Zeng,Yue Yang,Cheng Chen,Ligen Lin,Chunping Tang,Yuxiang Yang
标识
DOI:10.1021/acs.jnatprod.3c00253
摘要
Phytochemical investigation of the aerial parts of Vernonia solanifolia resulted in the isolation of 23 new highly oxidized bisabolane-type sesquiterpenoids (1–23). Structures were determined by interpretation of spectroscopic data, single-crystal X-ray diffraction analysis, and time-dependent density functional theory electronic circular dichroism calculations. Most compounds possess a rare tetrahydrofuran (1–17) or tetrahydropyran ring (18–21). Compounds 1/2 and 11/12 are pairs of epimers isomerized at C-10, while compounds 9/10 and 15/16 are isomerized at C-11 and C-2, respectively. The anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was evaluated for pure compounds. Compound 9 inhibited LPS-stimulated NO production at the concentration of 80 μM. It showed an anti-inflammatory effect by suppressing the activation of the NF-κB signaling pathway.
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