生物利用度
肽
药理学
自愈水凝胶
治疗指标
体内
药物输送
医学
化学
纳米技术
材料科学
药品
生物化学
生物
生物技术
有机化学
作者
Parham Sahandi Zangabad,Zahra Rezvani,Ziqiu Tong,Lars Esser,Roshan Vasani,Nicolas H. Voelcker
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-06-09
卷期号:6 (9): 3532-3554
被引量:2
标识
DOI:10.1021/acsabm.3c00193
摘要
Recent preclinical and clinical studies have focused on the active area of therapeutic peptides due to their high potency, selectivity, and specificity in treating a broad range of diseases. However, therapeutic peptides suffer from multiple disadvantages, such as limited oral bioavailability, short half-life, rapid clearance from the body, and susceptibility to physiological conditions (e.g., acidic pH and enzymolysis). Therefore, high peptide dosages and dose frequencies are required for effective patient treatment. Recent innovations in pharmaceutical formulations have substantially improved therapeutic peptide administration by providing the following advantages: long-acting delivery, precise dose administration, retention of biological activity, and improvement of patient compliance. This review discusses therapeutic peptides and challenges in their delivery and explores recent peptide delivery formulations, including micro/nanoparticles (based on lipids, polymers, porous silicon, silica, and stimuli-responsive materials), (stimuli-responsive) hydrogels, particle/hydrogel composites, and (natural or synthetic) scaffolds. This review further covers the applications of these formulations for prolonged delivery and sustained release of therapeutic peptides and their impact on peptide bioactivity, loading efficiency, and (in vitro/in vivo) release parameters.
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