化学
烷基化
氧化磷酸化
级联
级联反应
组合化学
有机化学
催化作用
生物化学
色谱法
作者
Zhuoyuan Liu,Yulin Sun,Mingshuai Zhang,Longkun Chen,Xuebing Chen,Xiang Li,Fuchao Yu
摘要
An Fe-mediated four-component reaction of enaminones, anhydrides and tetrahydrofuran through a cascade [1 + 2 + 3]-cyclization/esterification process is presented. This protocol provides a new and effective method to construct 4-alkylated 1,4-dihydropyridines with an ester fragment. Cyclic ether is employed as the C4 source of 1,4-dihydropyridines for the first time.
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