Impact of Bovine Serum Albumin on the Antioxidant and Anti‐Inflammatory Activities of Arbutus unedo L. Extract

This study explored the impact of bovine serum albumin (BSA) on the antioxidant and anti‐inflammatory activities of Arbutus unedo leaf extract and its polyphenolic compounds. HPLC‐MS analysis identified compounds like quinic acid, arbutin, and flavonoids. Antioxidant activity was evaluated using ferric reducing power, phosphomolybdenum, and DPPH assays, while anti‐inflammatory effects were assessed via red blood cell membrane stability. BSA enhanced hydroxyl radical scavenging but reduced ferric reducing power and total antioxidant capacity, with no significant anti‐inflammatory improvement. The findings reveal assay‐dependent effects of BSA due to protein–polyphenol interactions, emphasizing the need for further research to optimize therapeutic potential.