昼夜节律
视交叉上核
光对昼夜节律的影响
细菌昼夜节律
生物
激素
生物钟
时间生物学
振荡基因
句号(音乐)
时钟
神经科学
下丘脑
内分泌学
内科学
医学
物理
声学
作者
André Furtado,Diana Costa,Manuel C. Lemos,José E. Cavaco,Cecília R. A. Santos,Telma Quintela
出处
期刊:Advances in protein chemistry and structural biology
日期:2023-01-01
卷期号:: 39-81
标识
DOI:10.1016/bs.apcsb.2023.03.004
摘要
Molecular clocks are responsible for defining 24-h cycles of behaviour and physiology that are called circadian rhythms. Several structures and tissues are responsible for generating these circadian rhythms and are named circadian clocks. The suprachiasmatic nucleus of the hypothalamus is believed to be the master circadian clock receiving light input via the optic nerve and aligning internal rhythms with environmental cues. Studies using both in vivo and in vitro methodologies have reported the relationship between the molecular clock and sex hormones. The circadian system is directly responsible for controlling the synthesis of sex hormones and this synthesis varies according to the time of day and phase of the estrous cycle. Sex hormones also directly interact with the circadian system to regulate circadian gene expression, adjust biological processes, and even adjust their own synthesis. Several diseases have been linked with alterations in either the sex hormone background or the molecular clock. So, in this chapter we aim to summarize the current understanding of the relationship between the circadian system and sex hormones and their combined role in the onset of several related diseases.
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