NLRP6 governs hippocampal microglial phagocytosis to resist stress-induced depressive-like behaviors in mice and the intervention effect of bezafibrate

NLRP6 critically regulates microglial phagocytosis via CD36, combating depression. Bezafibrate alleviates stress-induced depressive behaviors and neuroinflammation primarily by enhancing NLRP6-dependent phagocytosis. Thus, NLRP6 represents a promising therapeutic target in hippocampal microglia for maintaining CNS homeostasis and treating depression.