Glucose-responsive nanozyme hydrogel for glycemic control and catalytic anti-infective therapy in diabetic wound healing

, generating a mildly acidic microenvironment. This acidity triggers the peroxidase-like activity of MOF(Zn-Fe) to produce hydroxyl radicals (•OH), enabling potent antibacterial effects and accelerating MOF degradation, thereby releasing insulin to restore normoglycemia. As glucose levels normalize, catalytic activity is self-terminated to prevent hypoglycemia. In vitro and in vivo studies confirmed robust antibacterial performance, enhanced angiogenesis, anti-inflammatory activity, and accelerated wound closure. Transcriptomic profiling further revealed upregulation of regenerative pathways and suppression of inflammatory and apoptotic signaling. This glucose-activated autonomous system provides a powerful strategy for diabetic wound management through synergistic glycemic control, anti-infection efficacy, and tissue regeneration.