Prognostic Impact of ALK Rearrangements in Resected NSCLC: A Systematic Review and Meta-analysis

Surgically resected ALK-rearranged NSCLC involves an increased risk of recurrence and reduced DFS, notably within the first 3 years, accompanied by higher rates of systemic and brain metastases. These findings underscore the importance of tailored postoperative surveillance strategies and suggest the potential role of perioperative ALK-tyrosine kinase inhibitors.