背景(考古学)
脂肪肝
肝病
肝损伤
疾病
非酒精性脂肪肝
肝炎
活性氧
程序性细胞死亡
酒精性肝病
医学
脂质过氧化
细胞凋亡
癌症研究
生物
生物信息学
免疫学
病理
细胞生物学
氧化应激
药理学
生物化学
内科学
肝硬化
古生物学
作者
Gaoyue Guo,Wanting Yang,Chao Sun,Xiaoyu Wang
标识
DOI:10.1080/10715762.2023.2232941
摘要
Ferroptosis is a novel form of cell death, manifested by iron-dependent, non-apoptotic manner resulting from the intracellular accumulation of large clusters of reactive oxygen species (ROS) and lipid peroxides due to abnormal iron metabolism. Since the liver is the main organ of human body for storing iron, it is essential to perform in-depth investigation on the role and mechanistic basis of ferroptosis in the context of divergent liver diseases. We previously summarized the emerging role of ferroptosis among various liver diseases, however, the past few years have been a surge in research establishing ferroptosis as the molecular basis or treatment option. This review article concentrated on the accumulating research progress of ferroptosis in a range of liver diseases such as acute liver injury/failure (ALI/ALF), immune-mediated hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease and liver fibrosis. Ferroptosis may be a promising target for the prevention and treatment of various liver diseases, providing a strategy for exploring new therapeutic avenues for these entities.
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