Anthocyanin attenuates high salt-induced hypertension via inhibiting the hyperactivity of the sympathetic nervous system

Excessive salt intake activates NLRP3-dependent inflammation and oxidative stress and increased AT₁R expression and function in the PVN. Bilateral PVN infusion of anthocyanin lowers peripheral sympathetic nerve activity and blood pressure in rats with salt-induced hypertension by improvement of expression and function of AT₁R in the PVN through inhibiting NLRP3 related inflammatory and oxidative stress.