MAPK/ERK通路
信号转导
医学
免疫学
白细胞介素33
诱饵
细胞因子
脂质信号
癌症研究
炎症
细胞生物学
白细胞介素
受体
生物
内科学
作者
Punniyakoti Veeraveedu Thanikachalama,Srinivasan Ramamurthy,Poojitha Mallapu,Sudhir Varma,Jayaraj Narayanan,Mohammed A. S. Abourehab,Prashant Kesharwani
标识
DOI:10.1016/j.cytogfr.2023.06.003
摘要
IL-33 belongs to the IL-1 family of cytokines, which function as inducers of Th2 cytokine production by binding with ST2L and IL-1RAcP. This, in turn, activates various signaling pathways, including the mitogen-activated protein kinase (MAPK), the inhibitor of Kappa-B kinase (IKK) pathway, and the phospholipase D-sphingosine kinase pathway. IL-33 has demonstrated protective effects against various cardiovascular diseases (CVDs) by inducing Th2 cytokines and promoting alternative activating M2 polarization. However, the soluble decoy form of ST2 (sST2) mitigates the biological effects of IL-33, exacerbating CVDs. Furthermore, IL-33 also plays a significant role in the development of asthma, arthritis, atopic dermatitis, and anaphylaxis through the activation of Th2 cells and mast cells. In this review, we aim to demonstrate the protective role of IL-33 against CVDs from 2005 to the present and explore the potential of serum soluble ST2 (sST2) as a diagnostic biomarker for CVDs. Therefore, IL-33 holds promise as a potential therapeutic target for the treatment of CVDs.
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