Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation

We herein report a highly enantioselective hydrogenation of α- N -heteroaryl ketones catalyzed by chiral ruthenium catalysts, furnishing β-heteroaryl amino alcohols in superb yields and enantioselectivities (up to 99% yield and up to 99% ee).