磁共振成像
萎缩
海马体
脑脊液
正电子发射断层摄影术
疾病
颞叶
语言学习
心理学
神经影像学
医学
听力学
病理
精神科
神经科学
认知
放射科
癫痫
作者
Jianping Jia,Yue Zhang,Yuqing Shi,Xuping Yin,Shiyuan Wang,Yan Li,Tan Zhao,Wenying Liu,Aihong Zhou,Longfei Jia
摘要
Alzheimer’s disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient’s cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-β 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.
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