化学
化学选择性
醛
催化作用
有机化学
联苯
氨基酸
酒
组合化学
生物化学
作者
Zhaowei Wu,Wei Wen,Qi‐Xiang Guo
出处
期刊:Tetrahedron
[Elsevier]
日期:2023-02-01
卷期号:132: 133235-133235
标识
DOI:10.1016/j.tet.2022.133235
摘要
A highly efficient biphenyl aldehyde-based ternary catalytic system is rationally designed and applied in the direct α-allylation reaction of N-unprotected amino acid esters and allyl alcohol acetates. The chemoselectivity of C-allylation and N-allylation is efficiently controlled and various racemic α,α-disubstituted amino acid esters are generated in good-to-high yields. The target products can be readily converted into structurally diverse α,α-disubstituted amino acids at a gram scale.
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