医学
烧心
胃肠病学
内科学
埃索美拉唑
食管炎
回流
反流(循环)
胃酸
胃
疾病
作者
Philip O. Katz,G.G. Ginsberg,Paul Hoyle,Mark Sostek,John T. Monyak,Debra G. Silberg
标识
DOI:10.1111/j.1365-2036.2006.03235.x
摘要
Summary Aim To assess the relationship between the percentage of time intragastric pH >4.0 and healing of erosive oesophagitis. Methods In this proof‐of‐concept study, adults with endoscopically verified Los Angeles grade C or grade D erosive oesophagitis were randomly assigned to oral esomeprazole 10 or 40 mg once daily for 4 weeks. On day 5, patients underwent 24‐h pH monitoring. At 4 weeks, erosive oesophagitis healing status was endoscopically assessed. Investigators scored gastro‐oesophageal reflux disease symptoms on a 4‐point scale [none to severe (0–3)] before and 4 weeks after treatment. The percentage of time intragastric pH was >4.0 and healing status were correlated and tested for significance using a Spearman rank correlation ( r ). Results 103 patients had evaluable data (mean age, 48.7 years; 65% men). Mean percentages of time with intragastric pH >4.0 on day 5 in patients with healed and unhealed erosive oesophagitis were 61% and 42%, respectively ( P = 0.0002), indicating that erosive oesophagitis healing rates were positively related to the percentage of time intragastric pH was >4.0. Greater intragastric acid control correlated with lower final daytime and night‐time heartburn and acid regurgitation symptom scores ( r = −0.029, −0.029 and −0.021; P = 0.003, 0.003 and 0.032, respectively). Conclusion A positive relationship between intragastric acid control and erosive oesophagitis healing was demonstrated.
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