The Role of the PGE2–Aromatase Pathway in Obesity-Associated Breast Inflammation

Abstract Subbaramaiah and colleagues present the first evidence indicating that a cyclooxygenase-2–prostaglandin E2–aromatase pathway promotes obesity-associated inflammation in women's breast tissues. Their findings shed new light on obesity-associated inflammation in general and provide a rationale for developing effective chemopreventive and therapeutic strategies targeting this pathway for obese women with breast inflammation and patients with hormone-dependent breast cancer. Cancer Discov; 2(4); 308–10. ©2012 AACR. Commentary on Subbaramaiah et al., p. 356.