医学
尖端扭转
心脏病学
心房颤动
内科学
钾通道
心室重构
心力衰竭
心脏病
钾通道阻滞剂
QT间期
作者
Vincent Algalarrondo,Stanley Nattel
标识
DOI:10.1016/j.ccep.2016.01.006
摘要
Heart disease produces substantial remodeling of K+ channels that in general promotes arrhythmia occurrence. In the case of ventricular arrhythmias, K+ channel remodeling contributes to the arrhythmic risk and increases vulnerability to torsades de pointes with K+ channel inhibiting drugs. Atrial K+ channel remodeling caused by atrial fibrillation promotes arrhythmia stability and presents opportunities for the development of new drugs targeting atrial inward rectifier K+ currents. A better understanding of K+ channel remodeling will help clinicians to appreciate arrhythmia mechanisms and determinants in a variety of clinical situations and to better manage arrhythmia therapy in patients with heart disease.
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