L型钙通道
电压依赖性钙通道
神经传递
神经科学
生物物理学
钙通道
生物
钙
化学
生物化学
受体
有机化学
作者
Lei Xu,Lilei Sun,Liangxu Xie,Shanzhi Mou,Dawei Zhang,Jingyu Zhu,Peng Xu
标识
DOI:10.2174/0929867327666200714154059
摘要
L-type Calcium Channels (LTCCs), also termed as Ca<sub>v</sub>1, belong to voltage-gated calcium channels (VGCCs/Ca<sub>v</sub>s), which play a critical role in a wide spectrum of physiological processes, including neurotransmission, cell cycle, muscular contraction, cardiac action potential and gene expression. Aberrant regulation of calcium channels is involved in neurological, cardiovascular, muscular and psychiatric disorders. Accordingly, LTCCs have been regarded as important drug targets, and a number of LTCC drugs are in clinical use. In this review, the recent development of structures and biological functions of LTCCs are introduced. Moreover, the representative modulators and ligand binding sites of LTCCs are discussed. Finally, molecular modeling and Computer-aided Drug Design (CADD) methods for understanding structure-function relations of LTCCs are summarized.
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