Study on making animal models of retinoblastoma

Objective To establish the animal models of retinoblastoma (Rb)in rabbit and nudemouse, and compare the achievement ratio of two groups.Methods 0.1 ml of Rb cell suspension were injectedinto chambers of 10 rabbits (10 eyes) ;0.4μl of Rb cell suspension were injected into chambers of 10 nudemice (10 eyes). Result In the group of rabbit,transplanted tumors were established in 2 eyes;and in thegroup of nude mouse,transplanted tumors were found in every experimental eyes.The transplanted tumorsshowed positive reaction to NSE,and negative reaction to GFAP.Conclusion Nude mouse is more suitablethan rabbit for making Rb animal model. Key words: Y79 cell; Animal model of Rb; Rabbit; Nude mouse; Anterior chamber