慢性疼痛
伤害
痛觉过敏
神经病理性疼痛
心理学
伤害感受器
痛阈
标识
DOI:10.1016/j.neulet.2020.135544
摘要
Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.
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