PTEN and AKT1 Variations in Childhood T-cell Acute Lymphoblastic Leukemia

Objective: gene variations and evaluated the clinical findings. Materials and Methods: genes by targeted next-generation sequencing. Results: variations. Conclusion: variation frequency makes it harder to investigate the clinical associations of the variants. On the other hand, characterization of the PTEN/AKT signaling members is important for improving case-specific therapeutic strategies.