二氢月桂酸脱氢酶
氧化磷酸化
嘧啶代谢
线粒体
生物化学
呼吸链
辅酶Q-细胞色素c还原酶
生物
线粒体呼吸链
线粒体DNA
核苷酸
酶
基因
嘌呤
细胞色素c
作者
Štěpána Boukalová,Soňa Hubáčková,Mirko Milošević,Zuzana Ezrova,Jiřı́ Neužil,Jakub Rohlena
标识
DOI:10.1016/j.bbadis.2020.165759
摘要
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
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