Efficacy of Thrice-Weekly Versus Once-Weekly Umbilical Cord Mesenchymal Stromal Cell Infusions for Steroid-Refractory Severe Acute Graft-Versus-Host Disease: A Retrospective Cohort Study

< 0.05). Despite the limitations of a retrospective design, these findings suggest that increased MSC infusion frequency might be associated with improved therapeutic efficacy and survival in severe SR-aGVHD. However, the potential confounding effect of cumulative dose cannot be excluded, and these results warrant validation in prospective randomized trials.