Silver-Catalyzed Enantioselective and Diastereoselective Aldol Reaction of α-Isocyanoacetates with Aldehydes Enabled by Cinchona-Derived Amide Adamantylphosphine Ligands

. Broad substrate scope was demonstrated with both aryl and alkyl aldehydes, and the method enabled atom-economical synthesis of key intermediates for thiamphenicol and chloramphenicol.