适体
生物
自愈水凝胶
焦磷酸盐
DNA
药物输送
滚动圆复制
指数富集配体系统进化
纳米技术
DNA纳米技术
计算生物学
纳米材料
生物物理学
组合化学
材料科学
生物化学
分子生物学
化学
聚合酶
核糖核酸
基因
酶
高分子化学
作者
Ysobel R Baker,Liyiwen Yuan,Jinfeng Chen,Roman Belle,Robert Carlisle,Afaf H. El‐Sagheer,Tom Brown
摘要
Rolling circle amplification (RCA) is a powerful tool for the construction of DNA nanomaterials such as hydrogels, high-performance scaffolds and DNA nanoflowers (DNFs), hybrid materials formed of DNA and magnesium pyrophosphate. Such DNA nanomaterials have great potential in therapeutics, imaging, protein immobilisation, and drug delivery, yet limited chemistry is available to expand their functionality. Here, we present orthogonal strategies to produce densely modified RCA products and DNFs. We provide methods to selectively modify the DNA component and/or the protein cargo of these materials, thereby greatly expanding the range of chemical functionalities available to these systems. We have used our methodology to construct DNFs bearing multiple surface aptamers and peptides capable of binding to cancer cells that overexpress the HER2 oncobiomarker, demonstrating their potential for diagnostic and therapeutic applications.
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