细胞生物学
抄写(语言学)
磷酸化
化学
核糖核酸
DNA
生物化学
生物
基因
语言学
哲学
作者
Yi Zhun Zhu,Gerald W. Hart
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2021-03-26
卷期号:49 (2): 867-880
被引量:12
摘要
O-linked-β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (PTM) that is actively added to and removed from thousands of intracellular proteins. As a PTM, O-GlcNAcylation tunes the functions of a protein in various ways, such as enzymatic activity, transcriptional activity, subcellular localization, intermolecular interactions, and degradation. Its regulatory roles often interplay with the phosphorylation of the same protein. Governed by 'the Central Dogma', the flow of genetic information is central to all cellular activities. Many proteins regulating this flow are O-GlcNAc modified, and their functions are tuned by the cycling sugar. Herein, we review the regulatory roles of O-GlcNAcylation on the epigenome, in DNA replication and repair, in transcription and in RNA processing, in protein translation and in protein turnover.
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