铜
离子
跟踪(教育)
缺血
尖点(奇点)
电化学
化学
材料科学
分析化学(期刊)
电极
皮质(解剖学)
神经科学
生物
物理化学
色谱法
有机化学
心脏病学
几何学
医学
数学
教育学
心理学
作者
Jiaqi Liu,Zhichao Liu,Weikang Wang,Yang Tian
标识
DOI:10.1002/anie.202106193
摘要
The imbalance of Cu+ and Cu2+ in the brain is closely related to neurodegenerative diseases. However, it still lacks of effective analytical methods for simultaneously determining the concentrations of Cu+ and Cu2+ . Herein, we created a novel SERS probe (CuSP) to real-time track and accurately quantify extracellular concentrations of Cu+ and Cu2+ in the live brain. The present CuSP probe demonstrated specific ability for recognition of Cu+ and Cu2+ in a dual-recognition mode. Then, a microarray consisting of 8 CuSP probes with high tempo-spatial resolution and good accuracy was constructed for tracking and simultaneously biosensing of Cu+ and Cu2+ in the cerebral cortex of living brain. Using our powerful tool, it was found that that the concentrations of Cu2+ and Cu+ were increased by ≈4.26 and ≈1.80 times upon ischemia, respectively. Three routes were first discovered for understanding the mechanisms of the increased concentrations of Cu+ and Cu2+ during ischemia.
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