Homogeneous Charge Compression Ignition (HCCI) engine is regarded as next generation engine in terms of high thermal efficiency and low emissions. However, it has some problems such as difficulty of controlling auto-ignition timing, knocking,and unburned gas. In this study, Methane which is high ignition temperature and DME which is low ignition temperature are applied to fuels, and the method of using Methane/DME mixing fuel is suggested to control auto-ignition timing. In addition, the effect of mixing proportion of Methane/DME on auto-ignition timing, auto-ignition temperature, and IMEP is searched.