化学
亲核细胞
对映选择合成
催化作用
衍生化
组合化学
氢化物
化学计量学
有机化学
高效液相色谱法
氢
作者
Michael Gribble,Sheng Guo,Stephen L. Buchwald
摘要
We show that a chiral copper hydride (CuH) complex catalyzes C–C bond-forming dearomatization of pyridines and pyridazines at room temperature. The catalytic reaction operates directly on free heterocycles and generates the nucleophiles in situ, eliminating the need for stoichiometric preactivation of either reaction partner; further, it is one of very few methods available for the enantioselective 1,4-dearomatization of heteroarenes. Combining the dearomatization with facile derivatization steps enables one-pot syntheses of enantioenriched pyridines and piperidines.
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