A Green and Efficient One-pot Synthesis of 1,2,3-Trisubstituted Pyrroles via Iodine-catalyzed Tandem Reaction

A green, efficient and operationally simple method for three-component synthesis of 1,2,3- trisubstituted pyrrole derivatives via an iodine-catalyzed tandem reaction has been developed, and a series of 1,2,3-trisubstituted pyrrole derivatives were synthesized from simple starting materials under neutral conditions, with good to excellent yields in short time. This method showcased the potential of great value as a mild, rapid, and general procedure for the synthesis of 1,2,3-trisubstituted pyrroles. Keywords: 1, 2, 3-Trisubstituted pyrrole, iodocyclization, multicomponent reaction (MCR), tandem reaction.