Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

Abstract By using the commercially available ruthenium pincer complex (Ru‐MACHO‐BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value‐added amino alcohols in good‐to‐excellent yields under mild reaction conditions. Remarkably, in addition to N ‐protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.