纳米笼
材料科学
纳米技术
表面等离子共振
光热治疗
表面改性
吸收(声学)
等离子体子
纳米结构
纳米颗粒
光电子学
化学工程
化学
复合材料
生物化学
工程类
催化作用
作者
Sara E. Skrabalak,Jingyi Chen,Leslie Au,Xianmao Lu,Xingde Li,Younan Xia
标识
DOI:10.1002/adma.200701972
摘要
Nanostructured materials provide a promising platform for early cancer detection and treatment. Here we highlight recent advances in the synthesis and use of Au nanocages for such biomedical applications. Gold nanocages represent a novel class of nanostructures, which can be prepared via a remarkably simple route based on the galvanic replacement reaction between Ag nanocubes and HAuCl(4). The Au nanocages have a tunable surface plasmon resonance peak that extends into the near-infrared, where the optical attenuation caused by blood and soft tissue is essentially negligible. They are also biocompatible and present a well-established surface for easy functionalization. We have tailored the scattering and absorption cross-sections of Au nanocages for use in optical coherence tomography and photothermal treatment, respectively. Our preliminary studies show greatly improved spectroscopic image contrast for tissue phantoms containing Au nanocages. Our most recent results also demonstrate the photothermal destruction of breast cancer cells in vitro by using immuno-targeted Au nanocages as an effective photo-thermal transducer. These experiments suggest that Au nanocages may be a new class of nanometer-sized agents for cancer diagnosis and therapy.
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