Amides from the Seeds of Piper nigrum Linn. and Their Insecticidal Activity

Two new amides pipertipine (1) and pipercitine (2) have been isolated from the dried seeds of Piper nigrum along with eight known constituents of βsitosterol, (2E, 4E, 8Z)-N-isobutyleicosatrienamide, pellitorine, guineensine, piperine, piperettine, pipericine, and (3,4-methylenedioxyphenyl)cinnamaldehyde.The structures of 1 and 2 have been elucidated as 1-[8-(3´, 4´-methylenedioxyphenyl)-(7E)-octaenoyl]piperidine and 1-[(2E)-octadecenoyl]piperidine, through extensive spectral studies including 2D NMR.New compounds 1 and 2 and most of the known exhibited toxicity against fourth-instar larvae of Aedes aegypti.Piper nigrum (black pepper) belonging to the Piperaceae family has over 700 species distributed in both hemispheres.It is acrid, pungent and is the most widely used spice in the world being rich in amides.][3]