诱导多能干细胞
心肌细胞
干细胞
药物发现
体外
细胞
细胞生物学
计算生物学
生物
心肌
荧光显微镜
心脏电生理学
大肠杆菌
荧光
电生理学
神经科学
生物信息学
胚胎干细胞
解剖
生物化学
基因
物理
量子力学
作者
Matthew Meselson,Franklin W. Stahl
标识
DOI:10.1073/pnas.44.7.671
摘要
With advancements in stem cell technology, in vitro models using iPSC (induced pluripotent stem cells)-derived cardiomyocytes (iPSC-CM) and engineered heart tissues (EHT) can serve as powerful tools for disease modeling and drug screening. ...Fluorescent reporters of cardiac electrophysiology provide valuable information on heart cell and tissue function. However, motion artifacts caused by cardiac muscle contraction interfere with accurate measurement of fluorescence signals. Although drugs ...
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