中医药
传统医学
中国
溃疡性结肠炎
医学
汤剂
肠道菌群
内科学
免疫学
替代医学
地理
病理
考古
疾病
作者
Yang Yang,Gang Chen,Qian Yang,Juan Ye,Xueting Cai,Pamo Tsering,Xiaolan Cheng,Chunping Hu,Shuangquan Zhang,Peng Cao
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2017-03-22
卷期号:8 (30): 48863-48874
被引量:82
标识
DOI:10.18632/oncotarget.16458
摘要
The gut microbiota, including probiotics and pathogenic microorganisms, is involved in ulcerative colitis (UC) by regulating pathogenic microorganisms and the production of intestinal mucosal antibodies.Huangqin decoction (HQD), a traditional Chinese formula chronicled in the Shanghan lun, has been recognized as an effective drug for UC, owing to its anti-inflammatory and anti-oxidative properties.In the present study, we investigated whether HQD ameliorates dextran sulphate sodium (DSS)-induced colitis through alteration of the gut microbiota.We found that HQD significantly inhibited colitis, alleviating the loss of body weight, disease activity index, colon shortening, tissue injury, and inflammatory cytokine changes induced by DSS treatment.Principal component analysis and principal co-ordinate analysis showed an obvious difference among the groups, with increased diversity in the DSS and DSS+HQD groups.Linear discriminant analysis effect size was used to determine differences between the groups.The relative abundance of Lactococcus was higher in the DSS+HQD group than in the DSS group, whereas Desulfovibrio and Helicobacter were decreased.Furthermore, the protective effect of HQD was attenuated only in antibiotic-treated mice.In conclusion, our results suggest that HQD could ameliorate DSS-induced inflammation through alteration of the gut microbiota.
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