Expression of P53 and Noxa in hippocampal CA1 area of rats with vascular dementia

Objective To investigate expression of P53 and Noxa in hippocampal CA1 area of rats with vascular dementia(VD),and to explore its pathogenesis.Methods Twenty-four adult SD rats were randomly divided into sham-operation group(n=12)and VD model group(n=12).VD rat models were established by bilateral occlusion of common carotid arteries.Morris water maze was used for place navigation test and spatial probe test.Neuropathological changes in hippocampus were observed with HE staining,and expression of P53,Noxa in hippocampal CA1 region was measured with immunofluorescence staining.Results The average latency in VD model group was significantly longer than that in sham-operation group(P0.01).The spatial memory in VD model group showed a significant impairment in comparison with that in sham-operation group(P0.01).Apoptosis was obvious in hippocampal CA1 area of VD rats with HE staining.In VD model group,the expression of P53 and Noxa in hippocampal CA1 region was higher than that in sham-operation group.The expression of P53 was postively correlated to expression of Noxa.Conclusion The increasing expression of P53 and Noxa may play an important role in the pathogenesis of vascular dementia.