Effects of compound Kudouzi on blood pressure, blood lipids and body weight in rats with spontaneously hypertension combined with hyperlipidemia

Objective To investigate the effects of different doses of compound Kudouzi on blood pressure, blood lipids and body weight in spontaneously hypertensive rats(SHR) combined with hyperlipidemia. Methods Rat model of SHR combined with hyperlipidemia was established with 48 SHR fed high-fat diet. The model rats were randomly divided into model group, compound Kudouzi high, medium and low dose groups, positive control group, normal Wistar rats group(n=10) and SHR control group(n=9).The systolic blood pressures(SBP) and body weight were measured before and after administration(at 1th, 2nd, 4th, 6th, 8thweeks); total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) in plasma were measured before and after administration(at 4th, 8thweeks). Results Compared with model group, SBP, TC, TG, LDL-C significantly decreased in high and middle doses of compound Kudouzi, HDL-C and body weight increased at the same time(P0.01). Conclusion Compound Kudouzi can reduce blood pressure, regulate blood lipids and improve lower body weight in model rats.