Clinical observation of 76 cases for application of nano-hydroxyapatite/polyamide 66(n-HA/PA66)biological activity artificial vertebral body in treatment of thoracolumbar burst fracture

Objective To evaluate the clinical effects of artificial vertebral body of biomimetic n-HA/PA66 composites in treatment of thoracolumbar burst fracture.Methods Seventy six cases with thoracolumbar burst fracture were included in this study.All patients were treated with the anterior approach,decompression of the spinal channel,interbody graft with the artificial vertebral body of n-HA/PA66 composites,and internal fixation.Results All cases were followed up for 6 to 60 months with out partial of general reaction.The reconstructive height of vertebra was maintained.The patients obtained bone union in 3 to 6 months after operation and vertebras conld be stable immedcately in long term without interface bone absorption and sinkage of artifical vertebra.Conclusion The artificial vertebral body of the biomimetic n-HA/PA66 composites reconstructing the height and structure of vertebra is a safe and effective method in treatment of thoracolumbar burst fracture,that can be a replacement of the autogenous iliac bone graft.