The Asian Pacific Association for the Study of the Liver(APASL) organized experts from Asian Pacific region to revise the chronic hepatitis B virus infection guidelines in 2015. The draft had been accomplished and promulgated at the 24 th APASL annual meeting in Istanbul this March. It had been interpreted item by item by Professor Shiv K. Sarin from India, and had been fully discussed at the meeting. According to information promulgated at the meeting, we will conclude and interpret the contents which are closely correlated to clinic, including basic concepts, diagnosis, treatment and patient management, for clinical doctor reference and application in practice.