Clinical and prognostic characteristics of single hormone receptor positive breast cancer

Objective To analyze the clinical and prognostic characteristics of single hormone receptor positive breast cancer.Methods Five hundred and sixty eihgtⅠ—Ⅲ breast cancer patients include 80 ER+/PR-subjects and 58 ER-/PR+ subjects admitted to Naval General Hospital from January 2000 to December 2004 were enrolled in this study.The clinical and prognostic character were compared.Results ER-/PR + tumors were found more frequently in younger,premenopausal women(P0.05).Survival analyses showed no difference between ER+/PR-and ER-/PR+ tumor in terms of disease-free interval and overall survival(P0.05).However,when compared with the double-negative phenotype,the ER+/PR-patients showed an association with better outcome but no survival advantage was detected in case of ER-/PR+ tumors.When compared with the double-positive phenotype,the ER-/PR+ group showed worse outcome whereas no such survival difference was detected in ER+/PR-tumors.Conclusion ER-/PR+ tumors are found more frequently in younger,premenopausal women,and its outcome is close to double-negative tumors;whereas ER+/PR-tumors outcome is close to double-positive tumors.