Objective To investigate the clinical efficacy of enteral nutrition support in patients with mechanical ventilation.Methods Eighty-four mechanically ventilated patients in intensive care unit(ICU) were divided into enteral nutrition(EN) group(n=42) and parenteral nutrition(PN) group(n=42).The PN group received energy by central venous pathways,while the EN group by nasogastric tube.Nutritional indicators,immune indicators and disease outcome indicators,complications in the two groups were observed before and after treatment.Results After treatment,nutrition indicators and immune parameters were significantly higher in the EN group than in the PN group.Mechanical ventilation duration and ICU admission duration were significantly less than in the PN group.Mortality and complications were significantly lower than in the PN group.Conclusion Enteral nutrition support can improve the mechanical ventilation in critically ill patients,nutritional status and immune function,and promote the rehabilitation of patients.